anish
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Post by anish on Jul 15, 2008 11:20:36 GMT -5
Sir, In India, all sorts of stem cell trials ON HUMANS have already started like adult, gene correction, umbilical, embryonic and now adipose too.
Hence I would like to know as to how you foresee the outcome ? While the risk might be there but since no case has been reported yet from past all the trials, hence I too am planning to participate.
This trial from adult adipose mesenecheymal stem cell (and above discussion) may start in 4 months, so I would like to have your opinion specifically for LGMD. (as my case stands). How much high are the percentage (STRONG) possibility for improvement ?
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anish
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Post by anish on Jul 15, 2008 11:36:17 GMT -5
And no use of immunosupressor.
This is the proposed treatment, please take note of all this dose and the delivery type. I depend on your reply.
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Post by David Feder on Jul 15, 2008 21:08:59 GMT -5
The risk is low but the result is unforeseeable (in all types of muscular dystrophy). But I am optimist with this therapy. You can see any positive effect. You will use related source of stem cells (any family for example?). If you will try you must do some evaluations before and after the procedure to have any confidence about result: lab tests, cardiac and respiratory functions, muscle force evaluation and others (as a clinical trial)
David
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Post by antonis on Jul 16, 2008 4:30:02 GMT -5
Sir, In India, all sorts of stem cell trials ON HUMANS have already started like adult, gene correction, umbilical, embryonic and now adipose too. Hence I would like to know as to how you foresee the outcome ? While the risk might be there but since no case has been reported yet from past all the trials, hence I too am planning to participate. This trial from adult adipose mesenecheymal stem cell (and above discussion) may start in 4 months, so I would like to have your opinion specifically for LGMD. (as my case stands). How much high are the percentage (STRONG) possibility for improvement ? Dear Anish If I am getting your post right it seems that an official trial is going to take place in India in about four months? Is it right? Could you give us more info or a link maybe?This is of my particular interest because my 7 year old son is suffering from a form of LGMD too. Thank you |
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anish
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Posts: 9
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Post by anish on Jul 17, 2008 2:44:44 GMT -5
Thank you david sir for all the answers. Now I will be able to decide very confidently
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anish
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Posts: 9
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Post by anish on Jul 17, 2008 2:53:45 GMT -5
Dear antonis,
There is nothing "official" about indian trials at present. All the research done are not regulated nor their is any regulatory law as per my knowledge. Also, these are done in confidentially till some results are out. It is out of choice people take the final route and is also charged beyond the reach of common man.
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Post by antonis on Jul 17, 2008 6:18:27 GMT -5
Dear Anish
Thanks for your kind reply.
I still have some questions.
Despite the secrecy,will the trial take place in an approved (govermential or not) hospital or a clinic in India?
Who will be the doctors?
I am telling you,because internet is full of <<clinics>> who offer stem cells treatments.Some of them appear in the advertisements banner of
this forum.
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Post by David Feder on Jul 19, 2008 18:20:50 GMT -5
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hb
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Post by hb on Jul 24, 2008 5:20:11 GMT -5
Dear David,
The manipal hospital treatment with donor mesenchymal stem cell did not work. Now it has been 15 months without any effect. I had 6 months, when the cpk came to normal levels but no physical improvement. Now after a year the degeneration is still ON.
Anyway, sir, now can the signals to mesenchymal stem cells which anish says make things better? I have also read that mesenchymal stem cell from adipose tisuue are in large volume and so without expansion the potential effect is retained.
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Post by David Feder on Jul 25, 2008 20:05:49 GMT -5
Hi Hb: nice to see your information again. I think that some citocines can improve the results. This is the work of researchers now. But we must see other variables: number of cells , arterial or venous administration, type of cells, immune response, etc.
David
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Post by antonis on Jul 27, 2008 1:27:52 GMT -5
Dear David, The manipal hospital treatment with donor mesenchymal stem cell did not work. Now it has been 15 months without any effect. I had 6 months, when the cpk came to normal levels but no physical improvement. Now after a year the degeneration is still ON. Dear hb I realise how disappointed you got after not seeing any physical improvements but I think that turning CPK to normal levels for 6 months is a great progress,something that no other treatment has managed to do. In my opinion this holds a great promise for the future and shows that things are moving.This is how the experience from the experts will be gained and come to the desired results someday. What is your opinion Dr Feder? |
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hb
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Posts: 19
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Post by hb on Jul 27, 2008 10:24:46 GMT -5
Dear David,
I agree that other factors will play important role and through this experiences the treatment can be optimized to get physical improvements. One more scientist expressed his view on email that "Unless something substantial is done with M-SC only 1-2% dystrophine will be produced, which is not sufficient to get physical improvement visibility".
Maybe, the simulation of stem cell to differentiate into muscle cell is "something substantial" ? is it ? This is the only advances, I find different with the trial mentioned by anish.
with regards
hb
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hb
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Post by hb on Jul 27, 2008 10:53:44 GMT -5
Dear antonis,
Yes I was disappointed when CPK got up again. I was very hopeful when my stamina got better and cpk was normal for those 6 months. Anyway, the doctors would find the missing link and hopefully something good will come to rescue. But for once this disease was defeated for those 6 months and for the first time in my whole life the cpk was normal indicating that there was no muscle damage then. It is certainly a step forward.
hb
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Post by David Feder on Jul 29, 2008 22:12:12 GMT -5
May me that some citocines could stimulate the differenciation of stem cells. The research of Dr. Cossu demonstrate that we have some variables to solve before stem cells therapy
PlGF–MMP-9–expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle
Cesare Gargioli, Marcello Coletta, Fabrizio De Grandis, Stefano M Cannata & Giulio Cossu - Italy
Sclerosis and reduced microvessel density characterize advanced stages of muscular dystrophy and hamper cell or gene delivery, precluding treatment of most individuals with Duchenne muscular dystrophy. Modified tendon fibroblasts expressing an angiogenic factor (placenta growth factor, PlGF) and a metalloproteinase (matrix metalloproteinase-9, MMP-9) are able to restore a vascular network and reduce collagen deposition, allowing efficient cell therapy in aged dystrophic mice. These data open the possibility of extending new therapies to currently untreatable individuals.
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hb
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Posts: 19
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Post by hb on Aug 1, 2008 1:51:10 GMT -5
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