Post by David Feder on May 16, 2009 18:23:11 GMT -5
(International Journal of Cardiology, 2009) Heart transplantation in 7 patients from a single family with limb-girdle muscular dystrophy caused by lamin A/C mutation
Pierre Ambrosi, Annick Mouly-Bandini, Sharam Attarian, Gilbert Habib - France
We describe 7 transplanted heart recipients from a single family with limb-girdle muscular dystrophy type 1B linked to a mutation of the LMNA gene in the splice donor site of the exon 9 (IVS 9+1:gNa). These patients did not display higher early postoperative or late complications than other heart transplant recipients at a mean follow-up of 8 years (range 1–17 years). Noticeably, there was no case of rhabdomyolysis and skeletal muscle symptoms were not markedly impaired.
Pierre Ambrosi, Annick Mouly-Bandini, Sharam Attarian, Gilbert Habib - France
We describe 7 transplanted heart recipients from a single family with limb-girdle muscular dystrophy type 1B linked to a mutation of the LMNA gene in the splice donor site of the exon 9 (IVS 9+1:gNa). These patients did not display higher early postoperative or late complications than other heart transplant recipients at a mean follow-up of 8 years (range 1–17 years). Noticeably, there was no case of rhabdomyolysis and skeletal muscle symptoms were not markedly impaired.