L-Arginine ?

[andreea]

Dear David,

I have recently read some article about oxidative stress (it's name: Oxidative stress, chronic diseases and muscle waisting, you can find it on Robin Sharp's site) . It said that "NOS catalize oxidation of L-arginine to L-citruline to release NO......NO has potential to negatively impact skeletal muscle..."

Do you think L-Arginine can be harmful for our boys? I give my son this as supplement and I am worried now that maybe it was not best thing.

Thank you in advance.

[David Feder]

I agree that L-arginine can help. You can read this two articles:

Persistent and improved functional gain in mdx dystrophic mice after treatment with L-arginine and deflazacort.

www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16464957

L-arginine improves dystrophic phenotype in mdx mice.

www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16137573

My son use Juven.
David

[Andy]

L-arginine can also act as a labido booster, i've been taking it for a while as i thought it might help with my LGMD ,

wondered why my labido was quite high , now I know why ...

[Tina]

How much juven does your son take? I am preparing to give this to my son. I will give him 2 packs a day. he weighs 60 pounds. He also has DMD.

If this is a labido enhancer- is there any relationship to how this product and viagra are said to help halt the progression of the DMD disease?

[David Feder]

My son use 1 pack each day. Yes, L-arginine and viagra act in the same reaction. I will try to find a scheme.

[David Feder]

Scheme:

L-arginine----------- NOS------------> NO

NO
GTP-------------------------------------> GMPc (cause the effects of NO)
(second messenger)
sildenafil
GMPc -----------------------------------> inactive

NO = nitric oxide
NOS = nitric oxide sintetase
L-arginine increase NO; NO increase GMPc
Sildenafil reduce inactivation of GMPc